Structure Determination by
May 13, 3:30-4:30 PM
Protein structure determination by single-particle cryo-EM has made significant progress in the past decade, with the resolution of recently reported structures improving close to 3 Å. Technical developments in all aspects of the cryo-EM method, including sample preparation, image collection and processing, will allow further improvements in resolution. Computational methods aid the interpretation of EM maps by rapidly analyzing shapes and surfaces. In combination, these methods promise the determination of finer structural details, sufficient for drug design. In this workshop, Dr. Jiang and Dr. Kihara will discuss the practical aspects of high-resolution structure determination by cryo-EM.